Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

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Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Cerebral dopamine neurotrophic factor (CDNF) protects the nigrostriatal dopaminergic (DA) neurons in rodent models of Parkinson's disease and restores DA circuitry when delivered after these neurons have begun to degenerate. These DA neurons have been suggested to transport striatal CDNF retrogradely to the substantia nigra (SN). However, in cultured cells the binding and internalization of ext...

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REFERENCES 1. BALY, F. A., History ofSouthport, Southport, Angus Downie, 1955, p. 37. 2. BmuxmHourr, J., An Essay on the Bite of a Mad Dog, London, R. Baldwin, 1783. 3. British Museum, Add. MS. 36876. 4. FoHRGLL, J., 'The Case of a Hydrophobia', in: Medical Observations and Enquiries, 2nd ed., 1779, vol. 5, p. 195. 5. HBYSHAM, J., Dissertatio Medica de Rabie Canina, Edinburgh, 1777. Information...

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ژورنال

عنوان ژورنال: eneuro

سال: 2017

ISSN: 2373-2822

DOI: 10.1523/eneuro.0128-16.2017